Malvern’s OMNISEC is a Gel Permeation Chromatography (GPC) / Size Exclusion Chromatography (SEC) system for the measurement of absolute molecular weight, molecular size, intrinsic viscosity, branching and other parameters. It includes OMNISEC RESOLVE, the integrated GPC/SEC module, OMNISEC REVEAL, the integrated multi-detector module and OMNISEC software for the characterization of synthetic and natural polymers, and proteins.
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|Control strength, toughness, durability, brittleness, processability and branching||Polystyrene, nylon, PET, PVC, polyester, nitrocellulose, resins, epoxys, polyurethanes, PVA|
|Measure degradation and drug delivery rates||PLA, PLGA, PEG, polycaprolocatone|
|Grade natural polymers and polysaccharides||Alginates, xanthans, Gum Arabic, starch derivatives (e.g. maltodextrin), cellulose derivatives (e.g. HEC), carageenan, gelatin, guar gum, chitosan, hyaluronic acid|
|Control formulation viscosity||Alkyds, acrylics, polyurethanes, polyesters, resins, epoxys, PVA|
|Control food mouth-feel and gelling||Pectins, alginates, xanthans, Gum Arabic, guar gum, starch derivatives (e.g. maltodextrin), carageenans|
|Assess and predict activity by measuring molecular weight||Proteins, antibodies, mAbs|
|Predict and understand immunogenicity and efficacy||Aggregates of proteins, biopharmaceuticals, biologics and mAbs|
|Control half-life, cell permeability and understand crystallization of protein conjugates||PEGylated proteins, membrane proteins, antibody-drug-conjugates|
|Pump flow rate||0.005 - 10 mL/min|
|Pressure range||0 - 5000 PSI (34.5 MPa)|
|Sample container types||HPLC vials or 96-well microtiter plates|
|Injection volume||1 - 300 µL|
|Syringe volume||250 µL standard|
Molecules are separated by their hydrodynamic radius
Better intrinsic viscosity measurements thanks to automated balancing
Reduced service cost and time thanks to user-exchangeable capillaries
Measure as little as 100 ng of material and molecular weights down to 200 Da
Malvern’s OMNISEC is a complete gel permeation/size exclusion chromatography (GPC/SEC) solution for the advanced characterization of synthetic and natural polymers, and proteins. This integrated GPC/SEC platform is made up of 3 components - OMNISEC RESOLVE, an integrated pump, degasser, autosampler and column oven; OMNISEC REVEAL, an integrated multi-detector; and OMNISEC software. This video describes the main features of OMNISEC and the benefits they bring to customers seeking the highest level of sensitivity and accuracy in their measurements of macromolecules.
Find out more about OMNISEC