Studies and regulatory

Please find enclosed some informations regarding published studies and regarding regulatory updates of barley beta-glucan.
The EFSA scientific opinion (October 2009)
Barley beta-glucane helps to maintain a normal level of the good blood cholesterol
Substantiates barley beta-glucan Health Claim in Article 13 of EC Regulation 1924/2006
Panel concluded that barley beta-glucans are sufficiently characterized
Panel concluded that a cause and effect relationship has been established between the consumption of barley beta-glucan and reduction of blood cholesterol concentrations
Panel concluded normal blood cholesterol concentrations are beneficial to human health
Applies to barley beta-glucans naturally present in foods and those forms added to foods
The claim is for consumption of at least 3 grams of barley beta-glucan daily
Barley beta-glucan (3 grams) may be provided in one or more servings. One serving must provide at least 25% (1/4th) of the daily consumption requirement
Target population is adults with normal or mildly elevated blood cholesterol levels
Panel concluded that beta-glucans from barley and oat have similar effects on cholesterol
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Behall, KM, Scholfield, DJ and J Hallfrisch 2004a. Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am. J. Clin. Nutr. 80: 1185-1193
Behall, KM, Scholfield, DJ and J Hallfrisch 2004b. Lipids significantly reduced by diets containing barley in moderately hypercholesterolemic men. J. Amer. Coll. Nutr. 23: 55-62
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Bourdon I, Yokoyama W, Davis P, Hudson P, Backus C, Richter R, Knuckles D, Schneeman et al 1999. Postprandial lipid, glucose, insulin and cholecystokinin responses in men fed barley pasta enriched with β-glucan Am. J. Clin. Nutr.69: 55-63
Brand-Miller JC 2003. Glycemic load and chronic disease. Nutr. Rev. 61: S49-S55
Brand-Miller JC, Hayne S, Petocz P and S Cloagiuri 2003. Low-glycemic index diets in the management of diabetes. Diabetes Care 26: 2261-2267
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Cavallero, A, Empilli, S, Brighenti, F and A M Stanca 2002: High (1-3,1-4)-b-D-glucan barley fractions in bread making and their effects on human glycemic response. J. Cereal Sci. 36: 59-66
Davis JM, Murphy EA, Brown AS, Carmichael MD, Ghaffar A and EP Mayer 2004. Effects of moderate exercise and oat β-glucan on innate immune function and susceptibility to respiratory infection. Am. J. Physiol. Regul. Integr. Physiol. 286: R366-R372
Dongowski, G, Huth, M, Gebhardt, E and W Flamme 2002. Dietary fiber-rich barley products beneficially affect the intestinal tract of rats. J. Nutr. 132:3704-14
Ebbeling CB, Leidig MM, Sinclair KB, Hangen JP and DS Ludwig 2003. A reduced glycemic load diet in the treatment of adolescent obesity. Arch. Pediatr. Adolesc. Med. 157: 773-779
Estrada A, Yun C, van Kessel A, Li B, Huata S, Laarveld B. Immunomodulatory activities of oat β-glucan in vitro and in vivo. Microbial. Immunol. 1997 41: 991-998
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Granfeldt Y, Liljeberg H, Drews A, Newman R Bjorck I 1994 Glucose and insulin responses to barley products: influence of food structure and amylose-amylopectin food structure. Am J Clin Nutr 59: 1075-1082
Hallfrisch, JG, Scholfield, DJ and KM Behall 2003. Comparison of glucose and insulin responses to barley and oats. Cer. Chem. 80:80-83
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Ikegami, S, Tomita, M, Honda, S, Yamaguchi, M, Mizukawa, R, Suzuki, Y, Ishi, K, Ohsawa, S, Kiyooka, N, Higuchi, M and S Kobayashi 1996. Effects of boiled barley rice feeding in hypercholesterolemic and normolipemic subjects. Plant Foods and Hum. Nutr. 49:317-328
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Jenkins AL, Jenkins DJA, Zdravkovic U, Wursch P and V Vuksan 2002. Depression of the glycemic index by high levels of β-glucan fiber in two functional foods tested in type 2 diabetes. J. Clin. Nutr. 56: 622-628
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Kabir, M, Oppert, J-M, Vidal, H, Bruzzo, F, Fiquet, C, Wursch, P, Slama, G and SW Rizkalla 2002. Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men. Metabolism 51: 819-826
Kanauchi, O, Iwanaga, T, Mitsuyama, K, Saiki, T, Tsuruta, O, Noguchi, K and A Toyonaga 1999. Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model. J. Gastroint. Hepatol. 14:880-8
Kaplan, R.J.; Greenwood, C.E.; Winocur, G.; Wolever, T.M.S. 2000: Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates. American Journal of Clinical Nutrition 72: 825-836.
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Knuckles, BE, Hudson, CA and MM Chiu 1997. Effect of beta glucan barley fractions in high fibre bread and pasta. Cereal Foods World 42: 94-99
Koh-Bannerjee, P, Franz, M, Sampson, L, Liu, S, Jacobs, DR Jr, Spiegelman, D, Willett, W and E Rimm 2004. Changes in wholegrain, bran and cereal fiber consumption in relation to 8-y weight gain among men. Amer. J. Clin. Nutr. 80:1237-1245
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Li, J, Kaneko, T, Qin, LQ, Wang, J and Y Wang 2003. Effects of barley intake on glucose tolerance, lipid metabolism and bowel function in women. Nutr 19:11-12, 926-929
Li, J, Wang, J, Kaneko, T, Qin, L-Q and A Sato 2004. Effects of fiber intake on the blood pressure, lipids and heart rate in Goto Kakizaki rats. Nutrition 20: 1003-7
Liljeberg H and Bjorck I 1994. Bioavailability of starch in bread products. Postprandial glucose and insulin responses in healthy subjects and in vitro resistant starch content. Eur J Clin Nutr 48: 151-163
Liljeberg, HGM, Granfeldt, YE and IME Björck 1996. Products based on a high fiber barley genotype, but not on common barley or oats, lower postprandial glucose and insulin responses in healthy humans. J. Nutr. 126: 458-466
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Pins, J, Geleva, D, Keenan, JM, Frazel, C, O’Connor, PJ and LM Cherney 2002. Do whole-grain oat cereals reduce the need for anti-hypertensive medications and improve blood pressure control? J. Fam. Pract. 51: 353-359
Rimm, EB, Ascherio, A, Giovanucci, E, Spiegelman, D, Stampfer, MJ and WC Willett 1996. Vegetable, fruit and cereal fiber intake and risk of coronary heart disease among men. JAMA 275: 447-541
Ripsin, CM, Keenan, JM, Jacobs, DR, Elmer, PJ, Welch, RR, Van Horn, L, Liu, K, Turnbull, WH, Thye, F, Kestin, M, Hegsted, M, Davidson, MH, Dugan, LD, Dehmark-Wahnefried, W and S Beling 1992. Oat products and lipid lowering: a meta-analysis. JAMA 267:3317-3325
Salmeron J, Ascherio, A, Rimm EB, Coldiz GA, Spiegelman D, Jenkins DJ, Stampfer MJ, Wing AL and Willet WC 1997a. Dietary fibre, glycaemic load and risk of NIDDM in men. Diabetes Care 20: 545-550
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Smith, K, Queenan, K, Thomas, W, Fulcher, G and J Slavin 2004. Study of cholesterol-lowering effect of β-glucan from barley in hypercholesterolemic subjects. FASEB J. 18: A149
Speith LE, Harnish JD, Lenders CM, Raezer RB, Pereira MA, Hangen SJ and DS Ludwig 2000. A low glycemic index diet in the treatment of pediatric obesity. Arch. Pediatr. Adolesc. Med. 154: 947-951
Stampfer MJ, Hu FB, Manson JE, Rimm EB and WC Willett 2000. Primary prevention of cornoary heart disease in women through diet and lifestyle. New Engl. J. Med. 343: 16-22
US Food and Drug Administration 2006. Food Labelling: Health claims; Soluble dietary fiber from certain foods and coronary heart disease. USFDA Fed. Reg. 71(98), pp. 29248-29250
Warren, JM, Henry, CJK, and V. Simonite 2003. Low glycemic index breakfasts and reduced food intake in preadolescent children. Pediatrics 112: e414
Wolk, A, Manson, JE, Stampfer, MJ, Colditz, GA, Hu, FB, Speizer, FE, Hennekens, CH and WC Willett 1999. Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. JAMA 281: 1998-2004
Yokoyama, W.H., Hudson, C.A., Knuckles, B.E., Chiu, M.C.M., Sayre, R.N., Turnlans, J.R. and B.O. Schneeman 1997: Effect of barley beta-glucan in durum wheat pasta on human glycemic response. Cereal Chem. 74: 293-296
Yoshizawa, M, Yokoyama, K Nakano, Y and H Nakamura 2004. Protective effects of barley and its hydrolysates on gastric stress ulcer in rats. Yakugaku Zasshi 124: 571-5
Yun CH, Estrada, A, van Kessel, A, Gajadhar, A, Redmond, M and B Laarveld 1997. b-(1-3, 1-4) oat β-glucan enhances resistance to Eimeria vermiformis infection in immunosuppressed mice. Int. J. Parasit. 27: 329-337
Yun CH, Estrada, A, van Kessel, A, Gajadhar, A, Redmond, M and B Laarveld 1998. Immunomodulatory effects of oat β-glucan administered intragastrically or parenterally on mice infected with Eimeria vermiformis. Microbial Immunol. 42: 457-465
