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Malvern - Drug Discovery - MicroCal Range

Microcalorimeters for characterization of biomolecular stability and interactions

MicroCal microcalorimeters are powerful, analytical tools used to study biological systems. These include interactions between molecules as well as changes in conformation such as protein unfolding. The technique is very convenient requiring only minimal assay development and NO labelling. The range includes both Differential Scanning and Isothermal Titration calorimetry.

MicroCal microcalorimeters are used in a wide range of applications from basic research to the discovery and development of small molecule drugs, biotherapeutics and vaccines. Our customers include pharmaceutical, biotech, academic and governmental research institutions worldwide.

MicroCal DSC range - Powerful analytical tools for characterizing the stability of proteins and other biomolecules

MicroCal DSC microcalorimeters are powerful analytical tools for characterizing the stability of proteins and other biomolecules, requiring minimal assay development, no labelling or immobilization. The automation and high sensitivity afforded by MicroCal VP-Capillary DSC systems permits screening of large numbers of samples at low concentrations minimizing the consumption of valuable samples with little hands-on effort.

MicroCal ITC range - Determine the binding parameters of biomolecules in a single analysis

MicroCal ITC isothermal titration calorimeters are used to study a wide range of biomolecular interactions. The applications range from drug design to fundamental research such as the understanding and regulation of signal transduction pathways. These systems deliver direct, label free and in-solution measurements of binding affinity and thermodynamic parameters in a single experiment. They have high sensitivity, low sample consumption and options for automation to minimize ‘hands on’ time. A choice of instruments ensures that MicroCal ITC calorimeters meet the varied and demanding requirements of today’s life science laboratories.

For applications about Malvern Microcal range, click here

DKSH is the exclusive distributor in Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Taiwan, Thailand and Vietnam.

 

Available models
Malvern MircoCal VP-Capillary DSC
Technical Specifications
Measurement
Temperature midpoint,Enthalpy,Heat capacity change
Temperature range
-10°C to 130°C
Sample capacity
576 (six 96 well plates)
Throughput
50 samples / 24 h (automated)
Sample volume
370 µL
Cell volume
130 µL
Cell material
Tantalum
Noise
0.05 µCal/°C
Typical Concentration
0.1 - 2.0 mg/mL
Maximum scan rate
240 ºC/h
Response time
5 s
Baseline repeatability
1.5 µCal/°C

Comprehensive stability studies made easy

The MicroCal VP-Capillary DSC is a highly sensitive, fully automated, high-throughput differential scanning calorimeter for characterizing protein and biomolecule stability. The resulting data provide critical guidance for biopharmaceutical development, from protein engineering, through pre-formulation and process development, to formulation of the final product. Unattended operation enables 24-hour working while integrated software streamlines workflow and data analysis, delivering results in hours and driving productivity in biopharmaceutical research.

 

Malvern MircoCal VP-DSC
Technical Specifications
Measurement
Temperature midpoint,Enthalpy,Heat capacity change
Temperature range
-10°C to 130°C
Sample capacity
2 - 5 samples / 8 h (manual)
Sample volume
700 µL
Cell volume
500 µL
Cell material
Tantalum
Noise
0.25 µCal/°C
Typical Concentration
0.1 - 2.0 mg/mL
Maximum scan rate
90 ºC/h
Response time
7 s
Baseline repeatability
1.25 µCal/°C

Exceptional sensitivity for research applications

The MicroCal VP-DSC is a highly sensitive, easy-to-use differential scanning calorimeter for the study of samples in solution. It is used to directly measure the intramolecular stability of structured macromolecules such as proteins and nucleic acids as well as the intermolecular stability of complexes such as oligomeric proteins, nucleic acid duplexes and lipid and detergent micellar systems.

Malvern MircoCal VP-ITC
Technical Specifications
Measurement
Enthalpy,Affinity,Entropy,Stoichiometry
Temperature range
2°C to 80°C
Sample capacity
4 - 8 samples / 8 h
Sample volume
2 mL
Cell volume
1400 µL
Injection syringe volume
300 µL
Cell material
Hastelloy
Noise
0.05 nCal/°C
Response time
20 s

Research insights into biomolecular interactions

The MicroCal VP-ITC is a powerful and sensitive, easy-to-use isothermal titration calorimeter that offers the ability to investigate any biomolecular interactions. This fast, convenient, label free and in-solution technique delivers the information needed to characterize the molecular interactions of proteins, antibodies, nucleic acids and other biomolecules. The system is widely used in research environments for lead optimization, hit validation, assessing the driving mechanisms of binding and studying enzyme kinetics and inhibitor design.

 

Malvern MircoCal iTC200
Technical Specifications
Measurement
Enthalpy,Affinity,Entropy,Stoichiometry
Temperature range
2°C to 80°C
Temperature stability
± 0.00015°C
Sample capacity
8 - 12 samples / 8 h
Sample volume
280 µL
Cell volume
200 µL
Injection syringe volume
40 µL
Injection volume precision
<1% @ 2µL
Equilibrium time
< 6 min (from 25°C to 5°C)
Cell material
Hastelloy
Noise
0.2 ncal/s
Response time
10 s

High sensitivity measurement of all binding parameters

The MicroCal iTC200 is a highly sensitive, low volume isothermal titration calorimeter for the label-free in solution study of biomolecular interactions. It delivers direct measurement of all binding parameters in a single experiment and can analyze weak to high affinity binders, using as little as 10 µg sample. Semi automated maintenance minimizes operator intervention and the system is upgradable to the fully automated MicroCal Auto-iTC200, making it ideal for laboratories where speed, sensitivity and the ability to accommodate higher workloads in the future are paramount.

 

Malvern MircoCal PEAQ-ITC Automated
Technical Specifications
Measurement
Enthalpy,Affinity,Entropy,Stoichiometry
Temperature range
2°C to 80°C
Temperature stability
± 0.00012°C
Sample capacity
384 (four 96 well plates)
Sample volume
370 µL
Cell volume
200 µL
Injection syringe volume
40 µL
Injection volume precision
<1% @ 2µL
Throughput
Up to 42 per 24 hr
Cell material
Hastelloy
Noise
0.15 ncal/s
Response time
8 s

High productivity measurement of multiple binding parameters

The MicroCal PEAQ-ITC Automated is a configurable, low volume, highly sensitive isothermal titration calorimeter which offers the convenience of unattended operation. It delivers direct, label-free in solution measurement of all binding parameters in a single experiment. Applications include characterizing molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. It can also be used to measure enzyme kinetics

 

Malvern MircoCal PEAQ-ITC
Technical Specifications
Measurement
Enthalpy,Affinity,Entropy,Stoichiometry
Temperature range
2°C to 80°C
Temperature stability
± 0.00012°C
Sample capacity
384 (four 96 well plates)
Sample volume
280 µL
Cell volume
200 µL
Injection syringe volume
40 µL
Injection volume precision
<1% @ 2µL
Throughput
8-12 per 8 hr
Cell material
Hastelloy
Noise
0.15 ncal/s
Response time
8 s

High sensitivity measurement of all binding parameters

The MicroCal PEAQ-ITC Automated is a configurable, low volume, highly sensitive isothermal titration calorimeter which offers the convenience of unattended operation. It delivers direct, label-free in solution measurement of all binding parameters in a single experiment. Applications include characterizing molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. It can also be used to measure enzyme kinetics

  • Measurements of binding affinity and thermodynamic parameters in a single experiment

  • High sensitivity with options for automation to minimize ‘hands on’ time

  • Low sample consumption

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What Is Differential Scanning Calorimetry (DSC)?

Malvern Instruments MicroCal DSC team introduce what Differential Scanning Calorimetry (DSC) is and why it is the gold standard in characterizing the stability of a protein or other biomolecules.

The Malvern MicroCal team details how Differential Scanning Calorimetry (DSC) works and why you should be using it for testing protein stability.

For more information on Scanning Calorimetry (DSC) here

  • Cambodia
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Malvern Instruments LimitedMalvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, microcalorimetry, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.
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