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Automated Cell Culture Analyzer with Maintenance-Free Chemistry Sensors

BioProfile FLEX2 combines Nova’s groundbreaking MicroSensor™ Card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume. The full 16 cell culture test menu includes: Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca++, pH, PCO2, PO2, total cell density, viable cell density, viability, cell diameter, and osmolality.

Compared to the previous generation BioProfile FLEX there is no maintenance for any of the 11 chemistry and gas sensors, sample volume for the full test menu is reduced by 75% to 275 microliters, and testing time is reduced to just 4.5 minutes. Automated sampling from 96-well plates, syringes, or a 24-position external “load-and-go” sample tray provides maximum workflow flexibility and efficiency for cell culture monitoring.

Technical Specifications

Analysis time and sample size when modules are run individually

Module Analysis Time Sample Size
Gas Module: pH, PCO2 , PO2 120 sec 275 μl
Chemistry Module: Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca++ 120 sec 135 μl
Osmometry Module: Osmolality 240 sec 145 μl
Cell Density/Viability Module: Total cell density, viability, cell diameter 240 sec 135 μl

Analysis time and sample size when all modules are run collectively

Module Analysis Time Sample Size
All Modules-All Tests 270 sec 275 μl

Key Features

  • FLEX2 Online Autosampler
  • FLEX2 and ESM integration with ambr® 250 and ambr 15 cell culture systems
  • Maintenance-free microsensor cards
  • Cartridge-based reagent management system (RMS)
  • Fast analysis time
  • Small sample volume
  • Walkaway automation
  • Onboard automated QC
  • Compliance with 21 CFR Part 11
  • GMP compliance

BioProfile FLEX2: Cell Culture Analyzer

Nova Biomedical® Bioprofile® FLEX2 with ambr

  • Biopharmaceutical and Biotechnology
Nova BiomedicalNova Biomedical develops, manufactures, and sells advanced technology blood testing analyzers. We employ over 1,400 people, with sales and service subsidiaries in eight countries and distributors in more than 91 additional countries. Nova has manufacturing facilities in Waltham and Billerica, Massachusetts; and Taipei, Taiwan. Nova is one of the 25 largest in vitro diagnostic companies in the world and the largest privately owned in vitro diagnostic company in the United States.