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The 708-DS Dissolution Apparatus is designed for reproducibility and ease of qualification, and is the ideal platform for standardizing dissolution testing. The rugged, yet versatile, instrument minimizes external variable influences and conforms to the USP Performance Verification Test (PVT) and enhanced Mechanical Qualification (MQ) standard recommended by the ASTM and FDA. The 708-DS can be configured for use with baskets (Apparatus 1), paddles (Apparatus 2), paddle over disk assemblies (Apparatus 5) and rotating cylinders (Apparatus 6), and can accommodate vessel sizes from 100 mL to 2L.

Technical specifications

Condition Performance may vary depending on environmental conditions
(temperature, humidity, altitude, etc.)
Evaporation Less than 1% evaporative loss under specific conditions
Ambient temperature 5 to 40 °C
Humidity (non-condensing) Not more than 80% RH
Sampling Manifold option available for automated sampling
Dimensions Width: 62.2 cm (24.5 in.)
Operating Height: 67.95 cm (26.75 in.)
Clearance Height: 99.06 cm (39 in.)
Depth: 59 cm (23.2 in.)
54.4 kg (120 lb) machine dry with vessels and paddles

Key features

  • Flexible sampling options: access to all vessels from the vessel plate ensures quick, simple manual sampling through the evaporation cover port. Or, automate your sampling using the motorized manifold and the 850-DS Dissolution Sampling Station.
  • Accurately measure and record individual vessel temperatures manually with the optional handheld temperature probe or automate this process with AutoTemp In-vessel Temperature Monitoring.
  • Automate your dosage delivery with the Dosage Delivery Module (DDM), or simply introduce samples by manual insertion through the evaporation cover port. Using the DDM feature allows you to precisely drop samples simultaneously or sequentially at a predetermined interval.
  • Customize your instrument with interchangeable dissolution accessory components. The common upper shafts support interchangeable baskets and paddles, yet maintain the correct height to save time when switching between configurations.
  • Easily navigate the touch panel display to setup, store and operate methods on the easy-to-read color display. The intuitive interface with screen-locking security features also offers multiple language options for English, Spanish, Japanese and Simplified Chinese.
  • Hands-free evaporation cover suspension offers a simple way to add media to the vessels, manually sample and measure physical parameters. The evaporation covers automatically raise/lower with the apparatus drive unit using either the alignment posts or DDM assemblies.
  • Ensure proper vessel alignment with the 708-DS’s TruAlign vessel. The incorporated plastic collar maintains accurate centering as well as ensures the vessel walls are perpendicular to the vessel plate. The indicator tab ensures reproducible vessel orientation.
  • Decrease cleaning time with the angled water bath - makes cleaning easy and efficient.
  • The easy-priming heater/circulator resides behind the water bath and beneath the vessel plate to save valuable bench space. It also contains vibration isolators to minimize vibration transmitted to the apparatus.
  • Integrate with Dissolution Workstation Software for automated control of up to four systems from one PC.

Agilent Intrinsic Dissolution Apparatus Technique

  • Aerospace
  • Agriculture
  • Automotive
  • Biopharmaceutical and Biotechnology
  • Chemical
  • Construction
  • Cosmetics & Personal Care
  • Defense
  • Die & Mould
  • Education & Academics
  • Electronics
  • Energy
  • Environmental
  • Food & Beverage
  • Luxury
  • Machinery & Manufacturing
  • Medical
  • Mining & Minerals
  • Oil & Gas
  • Optical
  • Paper & Wood
  • Pharmaceutical
  • Polymers, Plastics and Rubbers
  • Powders & Pigments / Coating
  • Railway
  • Semiconductor, Solar & Electronics
  • Service
  • Textile
  • Wholesale & Retail
Agilent TechnologiesAgilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent’s expertise and trusted collaboration give them the highest confidence in our solutions.
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