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The operating principle of this technique is based on the chromatographic analysis of the vapor phase in thermodynamic equilibrium above the sample enclosed in a sealed container. Analysis of residue solvents using GC Heaspace techniques, has become a major control procedure in pharmaceutical and food related industries. CARLO ERBA Reagents has recently developed solvents specifically tested for GC-HS applications. Their purity and handling specifications meet the requirements of the latest Pharmacopoeia guidelines for the residual solvent content pharmaceutical products.