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In HPLC, components of a mixture are carried through the stationary phase by the flow of a mobile phase and separation is based on differences in migration rates among the sample components. Therefore, the nature of your analytes defines not only the method but also the HPLC system.

Main characteristics of the analytes

  • Molecular weight defines the pore size of the stationary phase
  • Solubility defines the HPLC mode, the chemistry of the stationary phase, and the eluent.
  • Concentration and matrix define the detection parameters and column dimensions.

The elutropic series defines the solvent strength for the most often used chromatography modes normal phase and reversed phase.

Key Features

  • Isocratic binary high pressure gradient (HPG) or quaternary low pressure gradient (LPG) pump
  • Pump heads allowing flow rates up to 10 ml/min at 862 bar or 1000 bar up to 2 ml/min
  • Autosampler with 0.1 μl sample aspiration at max. 1240 bar with zero sample loss
  • Choice of highly sensitive UVD, MWD, DAD, or RID detectors with intelligent temperature control
  • Wide range of flow cells available, including remote cells
  • Finger-tight high pressure stainless steel capillary connections “K-Connect”
  • Extensive safety features such as leak management and sensors
  • Frontal access of detector lamp and pump head for easy maintenance

Available models

Knauer Azura Analytical HPLC Systems
Application area
Pump system
Quaternary LPG
Diode array detection DAD
ClarityChrom, Mobile Control
862 bar
Column thermostat

Eluent delivery

The Pump P 6.1L with LPG configuration has a new LPG valve for precise mixing efficiency of up to four eluents. The integrated degasser prevents air bubbles in the system. A mixing chamber is mounted on each Pump P 6.1L. This can be adapted to the respective application as required.

Sample Injection

The Autosampler 6.1L can inject 0.1 – 5000 µl to have a large flexibility. Using standard vials or two microtiter plates will give you a maximum sample capacity of up to 768 samples or 108 vials.

Column thermostating

The Column thermostat CT 2.1 is suitable for column thermostatization above and below room temperature. The instrument operates with a microprocessor controlled Peltier element for exact temperature settings.

Chromatography data system

KNAUER ClarityChrom® is a powerful, yet easy-to-use chromatography software for instrument control, data acquisition and data processing. It is an economical solution compared to other more complex chromatography software while still offering FDA 21 CFR Part 11 compliance.


The detector DAD 2.1L features a novel light path and flow cell architecture with improved handling and excellent performance. This Diode array detector can be used in the wavelength range of 190-700 nm.


AZURA Analytical HPLC and UHPLC Systems from Knauer

KnauerKNAUER manufactures high-end scientific instruments for research, routine analysis, quality assurance, and other applications. Supported technologies include liquid chromatography, precise handling and pumping of liquids up to high pressures, as well as flow-through detection of dissolved substances. Customizable products and solutions are one of our strengths. Made in Germany.