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The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on the customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • up to 16 KNAUER high-pressure dosing pumps 80P
  • up to 16 Coriolis flow meters
  • up to 8 KNAUER IJM mixers
  • Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
  • Outlet manifold for LNP solution
  • Back-seal washing system
  • The frame (stainless steel system 1.4301)
  • Installation & familiarization by KNAUER

In addition, we offer for our customers:

  • Customized Technical documentation which is order- and article-related
  • Customer Service before, during, and after the setup
  • Capillary customization and labeling
  • FAT (Factory Acceptance Test at KNAUER Berlin)
  • SAT (Site Acceptance Test at customer site)

Key Features

  • Made in Germany
  • Certified quality management
  • Customized solutions
  • Dedicated customer support

Technical Specifications

Number of impingement jets mixers up to 8
Number of pumps up to 16
Number of flow meter up to 16
Process connection inlet Sanitary Clamp Connector (2 Inlets)
Process connection outlet Sanitary Clamp Connector (1 Outlet)
Volumetric flow rate depending on configuration
Maximum operation pressure 50-70 bar
Liquid temperature range 4−60 °C (39.2−140 °F)
Wetted materials stainless steel, PEEK, Titanium, FFKM, PTFE, GFP (graphite fiber reinforced PTFE), aluminum oxide (Al2O3), ruby, sapphire
Software not included, necessary interfaces for the integration into PLC available
Interfaces Pump: LAN, RS-232, pin header connectors;
Flow meter: RS-232 + Industrial Interfaces;
Valve drive: LAN
Power supply Pump: 100–240 V, 50–60 Hz;
Flow meter: +15…24 V DC,
Maximum power consumption Values per device
Pump: maximum 320 W;
Flow meter: 3 W
Ambient conditions Temperature range: 4–40 °C; 39.2–104 °F; below 90 % humidity (non condensing)
Dimensions / Weight / API-predilution and quenching depending on configuration
GMP-ready documentation YES
Factory acceptance test YES
Site acceptance test YES
Purchase order lead time minimum 5 months, depending on customer requirements
Disclaimer Depending on the process the end user must consider the legal situation of patents and intellectual property. KNAUER is designing the customized hardware solution on customers request

Lipid Nanoparticle (LNP) Production for mRNA-based Vaccines

KnauerKNAUER manufactures high-end scientific instruments for research, routine analysis, quality assurance, and other applications. Supported technologies include liquid chromatography, precise handling and pumping of liquids up to high pressures, as well as flow-through detection of dissolved substances. Customizable products and solutions are one of our strengths. Made in Germany.