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Small-scale, multi-parallel bioreactors provide more process information for culture comparison in less time. Multiple experiments can assess different clones or cell lines, as well as the effects of pH, temperature, feeding, media, gassing rates and inoculation densities.

Ambr® multi-parallel bioreactors can handle your upstream process steps, from clone or cell line selection to process optimization, ensuring scalability because process data translates well into the 2L Univessel® SU and larger Biostat STR® systems.

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Available models

Ambr® 15 Cell Culture generation 2 is a high throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale. This platform enables selection of the best clones, media and feeds under small-scale bioreactor conditions, ensuring a seamless scale-up. Implemented in Cell Line Development (CLD) laboratories worldwide, Ambr® 15 Cell Culture makes experimentation more cost effective by saving on labor, facility space, capital, media and consumables.

 

  • New features: improved liquid handling, new culture station design, flexible deck layout and rapid vessel drain
  • Standard and cooled workstation configurations
  • Individual set point, monitoring and closed-loop control of pH and DO
  • Independent control of O2, CO2 and N2 for each microbioreactor
  • User-defined temperature and stirring set points for each culture station
  • Extended low speed stirring range down to 150 rpm
  • 10 – 15 mL working volumes
  • Single-use pH and DO sensors
  • Integrated pitched blade impeller
  • Port for liquid additions and for sampling
  • Vessels with sparge tube for gassing into the impeller mixing zone, or without for headspace gassing
  • Vessels available with temperature compensation for lower temperature applications

The Ambr® 250 High Throughput system is a high throughput, automated bioreactor system for process development with 12 or 24 fully featured single-use 100 – 250 mL mini bioreactors.

It has a wide range of applications in:

  • Process development and process optimization
  • Scale-down studies
  • Cell culture and microbial fermentation

Ambr® 250 High Throughput Perfusion is a parallel bioreactor system for rapid development of scalable perfusion processes using 100 – 250 mL single-use bioreactors and a fully automated liquid handling platform.

The system supports the typical range of hollow fibre cell retention applications, with up to 24 fully single-use perfusion bioreactors in parallel. This step-change in perfusion process development capability dramatically accelerates the optimization of intensified cell culture processes leading to lower production volumes and reduced cost of goods.

The system is capable of running in perfusion culture or fed-batch mode, depending on the type of ambr bioreactors installed, ideal for a wide range of biopharma and industrial biotech applications such as:

  • Process clone selection
  • Media development
  • Process optimization
  • Process characterization
  • Scale-down model development

Ambr® 250 Modular is an innovative, easy-to-use, expandable benchtop system that incorporates from 2 to 8 fully integrated single-use 100 – 250 mL mini bioreactors.

It has a wide range of applications in:

  • Process optimization
  • Process characterization

Key Features

  1. Isocratic and gradient configurations for resin, monolith, and membrane chromatography
  2. Flexibility in using 3/8 in. and 1/2 in. single-use flow kits
  3. Unique pinch valve block technology simultaneously reduces the void volume and enables easy flow kit installation
  4. Ready to operate with pre-calibrated single-use sensors
  5. Compact system design with maneuverable HMI
  6. cGMP compliant design and documentation
  • Biopharmaceutical and Biotechnology
Sartorius Lab InstrumentsThe Sartorius Group is a leading international partner of the biopharmaceutical industry and the research sector. We are helping biotech scientists and engineers across the entire globe to develop and manufacture medications from the first idea to production. So more people will have access to better medicine.
[Sartorius, bioreactor, cell culture, cell cultivation, upstream process, upstream, fermentor, fermenter, stirred tank, lab scale, r&d, research and development]