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Innovation at Your Fingertips

RedShiftBio's AQS³pro overcomes many of the limitations of traditional spectroscopy-based technologies with ultrasensitive, highly reproducible, automated structural measurements of proteins and other biomolecules. It can be used for a wide range of applications from formulation development of mAb-based biotherapeutics to robust measurements of ADCs, AAVs, and mRNA. Powered by Microfluidic Modulation Spectroscopy (MMS), the AQS³pro is designed to provide five key measurements— aggregation, quantitation, stability, similarity, structure—directly supports biomolecule characterization throughout the biopharmaceutical development pipeline.

Key features:

  • Ability to measure wide range of native sample concentrations from <0.1 mg/ml to >200 mg/ml
  • Fully automated sample-handling, with both 24 and 96 well plate formats
  • Real-time background subtraction eliminates need to dialyze samples
  • Detection of <2% change in secondary structure even at low concentrations
  • Advanced onboard data analytics enabling rapid and robust data interpretation and reporting

Technical Specifications

System Summary
Measurement Method Microfluidic Modulation Spectroscopy
Measurement Type Mid-Infrared Absorption
Supported Protein Measurements Secondary Structure, Similarity, chemical and quenched
Sample
Concentration Range 0.1 to >200 mg/mL
Typical Repeatability >98% with 2 mg/mL Lysozyme in water (area of overlap)
Dimensions and Weights
Analyzer Unit 22 H x 18.25 W x 18.5 D, 80 lbs
Electronics Unit 25 H x 10.5 W x 18 D, 40 lbs

The Benefits Of Microfluidic Modulation Spectroscopy (MMS)

MMS is a novel technology for label-free biomolecule analysis of protein aggregation, quantitation, stability, structure and similarity that directly addresses the limitations of current technologies. MMS provides drift-free, background subtracted, high sensitivity measurements of the protein secondary structure to facilitate major improvement in development of biopharmaceuticals.

  • 30x sensitivity to detect pivotal changes in structure over wide concentration ranges compared to traditional FTIR.
  • Fully automated sample-handling system with 96-well plate option.
  • Outstanding reproducibility that enables biomolecule analysis in complex buffers.
  • Inbuilt advanced data analytics enabling rapid and robust data interpretation and reporting, with an optional 21-CFR part 11 data compliance package.
  • Reducing development time.
  • Improving product quality.
  • De-risking development.
  • Increased confidence in data quality which leads to more efficient decision making.
  • Optimizing process design and development.

Learn about the AQS³pro - The Next Generation in Protein Characterization

AQS³pro Demonstration

RedShiftBio

RedShiftBio is redefining the possibilities for structural characterization of biomolecules.

RedShiftBio has developed a proprietary life sciences platform combining our Microfluidic Modulation Spectroscopy (MMS) and expertise in high powered quantum cascade lasers that provides ultra-sensitive and ultra-precise measurements of molecular structure. These structural changes affect critical quality attributes governing the safety, efficacy, and stability of biomolecules and their raw materials.

This combination of technologies is available to researchers in our fully-automated AQS³pro Analyzer and is backed by a global network of sales, applications, service, and support teams to address all market needs. Led by an experienced management team with a proven track record of success in both large instrumentation companies and commercializing disruptive technologies, RedShiftBio is here to support your research and development goals. Our instruments can be found in the majority of the leading biopharmaceutical companies in the world.

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