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Extensive portfolio of LC/MS instruments

Agilent’s portfolio of LC/MS instruments takes the versatility of HPLC separation to another level with the sensitivity and specificity of mass spectrometry. 

Add easy-to-use mass selective detection to your HPLC analyses with single quadrupole (SQ) LC/MSD. Achieve quantitative precision with triple quadrupole (TQ) systems that break sensitivity and size barriers. Go untargeted and see more while identifying unknowns using time-of-flight (TOF/Q-TOF) technology that delivers simultaneous accuracy, speed, and isotopic fidelity. The reliable family of Agilent LC/MS instruments provides a range of capability and performance to solve any LC/MS analysis challenge.

Available models

Technical specifications
MRM sensitivity IDL; ESI positive
IDL < 10.0 fg
  • Measured using 20 fg reserpine on-column
  • Quantifying on the MRM transition of  m/z 609 to m/z 195
  • Tested during manufacturing and confirmed on-site during installation

Ultivo is a stackable Liquid Chromatography Triple Quadrupole (LC/TQ) mass spectrometer that eliminates the MS footprint by incorporating the MS into the LC stack, and represents a transformative approach to LC/TQ. Ultivo triple quadrupole LC/MS provides the performance found in larger comparable systems, but at a fraction of their size. 

Innovations such as the Vortex Collision Cell, Cyclone Ion Guide, and VacShield provide users the sensitivity, robustness, reliability, and performance required for the day-in, day-out challenges of high-throughput sample analysis. Now with the addition of an ESI-only model, and features geared to assist you with 21 CFR Part 11 compliance, the Ultivo LC/TQ continues to reshape expectations, reinvent capabilities, and redefine what’s possible when small meets powerful.

Key features

  • Smallest footprint of any LC/TQ on the market, delivering a price-performance per square foot ratio that leads to reduced costs and the fastest path to achieving ROI.
  • Greater signal and reduced noise – Agilent Jet Stream Technology uses super-heated nitrogen to improve ion generation and desolvation
  • Instrument innovations for enhanced results:
    • VacShield – eliminates the need to vent the system while performing ion injector maintenance so instrument maintenance downtime is minimized and laboratory efficiency is increased.
    • Cyclone Ion Guide – compresses the ion beam without loss of signal, resulting in higher ion transmission efficiencies and enhanced data quality.
    • Vortex Collision Cell – provides efficient dissociation of ions in the cell, improved focusing and transmission of ions, rapid clearance of the cell between mass transitions, thereby allowing for more MRMs/sec, zero crosstalk and greater confidence in results by removing noisy background.
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantification with the generation of a product ion spectrum for compound screening and confirmation.
  • The intuitive operational design of the “Quant-My-Way” software feature and the MassHunter Productivity App provide boosts in productivity by up to 40%: require less need for operator training, reduce time reviewing data and simplify report generation.
  • Enhanced Maintenance Feedback (EMF) features centered on smart, self-aware diagnostics ensure optimum uptime and help to drive down maintenance costs
  • Combine with MassHunter software, OpenLab ECM 3 series (3.5 and above software ) and IQ/OQ services provide data integrity tools to assist you in achieving compliance readiness.
  • Optimized for unparalleled performance and advanced efficiency when paired with Agilent’s market leading portfolio of analytical LC systems and associated consumables.
  • Put CrossLab services to work for you; consultative support for workflow enablement, lab analytics, compliance, inventory management, asset management and relocation services

With its dual ion-funnel design, the Agilent 6495B triple quadrupole LC/MS system is ideally suited for peptide quantitation, food safety, environmental testing, forensics, clinical research, and other demanding applications. The Agilent Jet Stream ion source, hexabore capillary, and curved geometry collision cell combine to deliver the utmost in sensitivity among commercially available TQ LC/MS. The enhanced performance of this tandem quadrupole mass spectrometer makes it a perfect option for applications where you need extended mass range as well as consistent day-in, day-out operation. 

The Agilent 6495B triple quadrupole LC/MS system is at the forefront of robustness. It even includes a gate-valve assembly for quick and efficient maintenance of the hexabore capillary. Make this sensitive yet rugged instrument the cornerstone to your workflow.

Key features

  • Agilent's most sensitive LC/TQ –  up to attomole-zeptomole levels using iFunnel Technology
  • Enhanced assay performance using efficient ion sampling and transmission
  • Reliable and robust performance from enhanced ion optic lenses
  • Efficient ion detection and quantification using high-energy conversion dynode and low-noise characteristics
  • Gate Valve Technology – perform ion source maintenance without having to vent the instrument 
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantification with the generation of a product ion spectrum for library searching and compound screening and confirmation

The Agilent 6470A triple quadrupole LC/MS system delivers robust performance for commercial, regulatory, life sciences, and research applications. The 6470A UHPLC MS/MS system employs two technological advantages: Agilent Jet Stream ion source and curved geometry collision cell. These innovations enable you to reliably detect target compounds at low levels in diverse matrices, while achieving wide linear dynamic range. 

The 6470A LC/MS/MS triple quadrupole provides best-in-class sensitivity, precision, and scan speed, so you can dilute or use less sample and still have complete confidence in the accuracy of your results. The system’s proven robustness and reliability mean less maintenance and more uninterrupted laboratory productivity.

Key features

  • Enhanced sensitivity - detection limits up to sub-femtogram level 
  • Greater signal and reduced noise - Agilent Jet Stream technology uses super-heated nitrogen to improve ion generation and desolvation.
  • Compact design – reduced benchtop footprint
  • Secure investment with the flexibility to upgrade to Agilent iFunnel Technology
  • Efficient collection and transmission of product ions from innovative curved and tapered hexapole assembly
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation

The Agilent 6420A Triple Quadrupole LC/MS System is equipped with performance specifications in Signal-to-Noise ratio (S/N) and Instrument Detection Limit (IDL) for routine analysis.

Key features

  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation.
  • Efficient analysis – fast MRM speeds allow for analysis of over 100 overlapping compounds in a given retention time window
  • Fast polarity switching for analysis of both positive and negative ions
  • Secure investment – upgradable to the Agilent 6460C with Agilent Jet Stream technology for greater signal and reduced noise

The Agilent 6460C Triple Quadrupole LC/MS System is equipped with Agilent Jet Stream Technology to enable enhanced sensitivity. The 6460 provides a fast and robust solution to simultaneously quantify, screen, and confirm analytes in the laboratory.

Key features

  • Greater signal and reduced noise - Agilent Jet Stream technology uses super-heated nitrogen to improve ion generation and desolvation
  • Efficient analysis – fast MRM speeds allow for analysis of over 100 overlapping compounds in a given retention time window
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation
  • Fast polarity switching for analysis of both positive and negative ions
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Agilent TechnologiesAgilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent’s expertise and trusted collaboration give them the highest confidence in our solutions.
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