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Characterizing Nanoparticles: Visualizing, Sizing and Concentration

The Malvern NanoSight range of instruments provides an easy-to-use, reproducible platform for nanoparticle characterization. Nanosight range utilizes Nanoparticle Tracking Analysis (NTA) to characterize nanoparticles from 10 nm - 2000 nm in solution.

Each particle is individually but simultaneously analyzed by direct observation and measurement of diffusion events. This particle-by-particle methodology produces high resolution results for particle size distribution and concentration, while visual validation provides users with additional confidence in their data. Both particle size and concentration are measured, while a fluorescence mode provides differentiation of labelled or naturally fluorescing particles.


For applications about Malvern nanosight, click here

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Available models

Malvern NanoSight NS300
Technical Specifications
Particle size range
10 nm to 2000 nm
Concentration range
10⁶ to 10⁹ particles per mL
Wavelength
405 nm (violet), 488 nm (blue), 532 nm (green) or642 nm (red)
Temperature control range
5°C below ambient to 55°C
Dimensions (W × D × H)
400 mm × 250 mm × 400 mm
Power
110 V - 220 V
Stage
Fixed stage
Focus
Computer controlled motorized focus
Camera
sCMOS
Fluorescence
Motorized 6-place filter wheel with choice of filters

Optimized for Fluorescence Work

Malvern NS300 allows rapid, automated analysis of the size distribution and concentration of all types of nanoparticles. Sample temperature is fully programmable through the Nanoparticle Tracking Analysis (NTA) software. WIth the ability to be supplied with interchangeable laser modules and the introduction of a motorized 6-place filter wheel means different fluorescent labels can be analyzed.

Malvern NanoSight NS500
Technical Specifications
Particle size range
10 nm to 2000 nm
Concentration range
10⁶ to 10⁹ particles per mL
Wavelength
405 nm (violet), 488 nm (blue), 532 nm (green) or642 nm (red)
Temperature control range
5°C below ambient to 55°C
Dimensions (W × D × H)
530 mm × 250 mm × 400 mm
Power
110 V - 220 V
Sample conductivity range
0.005 mScm⁻¹ - 5mScm⁻¹
Stage
Computer controlled motorized stage
Focus
Computer controlled motorized focus
Camera
CCD or sCMOS
Fluorescence
Manual push / pull filter holder with 2 filters

Single Particle Zeta Potential Platform with Integrated Fluidics for Automation

Malvern NS500 provides detailed and intuitive analysis of the size distribution and concentration of all types of nanoparticles. Single particle zeta potential measurements on the NS500 provide inherent high resolution zeta distributions which can be measured simultaneously with other NTA measurements parameters like size, particle concentration and can even operate whilst in fluorescence mode.

Samples are introduced into the viewing chamber using the integrated fluidics capbility. On-screen pump control allows for automatic sample handling, including loading, washing and dilution. Software-controlled motorized optical stages enable rapid relocation and refocusing following cleaning, improving reproducibility. Sample temperature is fully programmable through the Nanoparticle Tracking Analysis (NTA) software.

  • Simultaneous measurement of multiple characteristics saves time and sample volume

  • Visual validation of results gives extra confidence

  • User friendly software with easy set up of SOPs for routine use

  • Minimal sample preparation

  • Choice of laser wavelengths

Nanoparticle Tracking Analysis - Nanosight NS300

The Malvern NanoSight NS300 Instrument provides an easy-to-use, reproducible platform for nanoparticle characterization using Nanoparticle Tracking Analysis. Find out more here

The NS300, which is optimized for fluorescence work, allows rapid, automated analysis of the size distribution and concentration of all types of nanoparticles from 10nm to 2000nm in diameter, depending on the instrument configuration and sample type.

The introduction of a motorized 6 place filter wheel controlled from within the software means multiple labels can be analyzed. A software-controlled motorized optical stage enables rapid relocation and refocusing following cleaning, improving reproducibility. Sample temperature is fully programmable through the Nanoparticle Tracking Analysis (NTA) software.

  • Aerospace
  • Biopharmaceutical and Biotechnology
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  • Environmental
  • Food & Beverage
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  • Optical
  • Paper & Wood
  • Pharmaceutical
  • Polymers, Plastics and Rubbers
  • Powders & Pigments / Coating
  • Semiconductor, Solar & Electronics
  • Textile
Malvern PanalyticalMalvern Panalytical was formed by the merger of Malvern Instruments Limited and PANalytical B.V. on 1st January 2017, has headquarters in both Almelo (the Netherlands), and in Malvern (UK), and employs over 2,000 people worldwide. The combined entity is a strong player and innovator in the materials characterization market and will leverage the strengths of the individual companies in their end markets, ranging from building materials to pharmaceuticals and from metals and mining to nanomaterials.
[nanosight, particle size, particle concentration]