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Industry-Leading InfinityLab Analytical LC Solutions

Agilent InfinityLab solutions for analytical LC include highly efficient HPLC and UHPLC systems that feature latest technology while maintaining full compatibility with legacy LC instrumentation. The 1220 Infinity II LC delivers high-quality results for an affordable price. The 1260 Infinity II LC is the flexible instrument choice for operational efficiency with the 1260 Infinity II Prime LC bringing more operational convenience. The 1290 Infinity II LC embodies the next generation of liquid chromatography with ultrahigh performance for superior outcomes.

Available models

1260 Infinity II Prime LC System

Highest analytical LC efficiency with confidence and convenience 

Within the 1260 Infinity II LC portfolio, the 1260 Infinity II Prime LC offers the highest functionality and operational convenience for analytical HPLC and UHPLC. The pressure range up to 800 bar for flow rates up to 5 mL/min helps you to achieve highest separation performance in terms of accuracy and precision for utmost confidence in your results. Instrument automation capabilities reduce the need for manual interaction, giving you a new level of convenience in your everyday analytical work.

Key features

  • 1260 Infinity II Flexible Pump – offers ultimate performance in terms of accuracy and precision for flow rates up to 5 mL/min within a pressure range up to 800 bar.
  • Seamless transfer of methods  between LCs  regardless of the brand - facilitated by Agilent’s proprietary Intelligent System Emulation Technology (ISET) as part of the pump, delivering unchanged retention time and peak resolution.
  • Simplify your workflow – the pump driver-based feature BlendAssist delivers accurately buffer/additive blending without manual interaction.
  • Reduce the need for manual interaction – with the Multipurpose valve built into the 1260 Infinity II Flexible Pump you can purge your instrument via software.
  • Ultralow carryover – the multiwash capability of the new 800 bar rated 1260 Infinity II Multisampler cleans all relevant injection parts between runs. This sophisticated, integrated feature flushes the injection needle outside with three solvents, and uses seat backflush procedures to reduce carryover to less than 10 ppm.
  • Efficient sample handling and logistics – using shallow well-plate drawers, the 1260 Infinity II Multisampler takes a maximum load of 16 microtiter plates and up to 6,144 samples – the most of any single system.
  • Efficient column handling and temperature control – the 1260 Infinity II Multicolumn Thermostat holds up to four columns with direct access to each column through a InfinityLab Quick Change switching valve, eliminating the need to disconnect and reconnect columns.
  • Improved flexibility - set up your LC system to suit the way you work, with the InfinityLab Benchtop shelving system
  • Stay at your desk – with the new InfinityLab LC Companion local user interface you can access and control your instrument comfortably from your office or other locations.
  • Perfect front-end for everyday MS analysis – performing like a high-pressure mixing system and offering convenient features to get to the optimum results faster.

The 1260 Infinity II LC offers the widest choice of modules for analytical HPLC and UHPLC. Reliable instrumentation combines with latest column technologies and advanced supplies to guarantee robust separation and detection performance. Easy column handling and superior sample logistics, from sample submission to data analysis, ensure fast turnaround times and highest instrument utilization. Seamless method transfer and stepwise upgrade paths facilitate risk-free integration in current infrastructure, for nondisruptive transition to highest performance within the confines of your budget. 

Key features

  • Compatible with conventional and ultrahigh performance LC – with an operating pressure of up to 600 bar, the 1260 Infinity II Quaternary Pump and the 1260 Infinity Binary Pump are a perfect match for our Poroshell 120 columns. 
  • Analytical and semi-preparative purifications - the wide flow range of the 1260 Infinity II Quaternary Pump (up to 10 mL/min) perfectly supports standard and semi-preparative applications. 
  • Fast and precise gradients – the 1260 Infinity II Binary Pump is the perfect choice for fast and precise gradients using LC/MS, as well as UV-only systems.
  • Ultralow carryover – the multiwash capability of the 1260 Infinity II Multisampler cleans all relevant injection parts between runs. This sophisticated, integrated feature flushes the injection needle outside with three solvents, and uses seat backflush procedures to reduce carryover to less than 10 ppm.
  • Reduced cycle times – with Agilent’s unique dual-needle design, which allows you to run samples alternately through one or the other injection path. Cycle times can be reduced to mere seconds, virtually eliminating conventional wait times – whether for large volume loadings or flushing procedures.
  • Efficient sample handling and logistics – using shallow well-plate drawers, the 1260 Infinity II Multisampler takes a maximum load of 16 microtiter plates and up to 6,144 samples – the most of any single system.
  • Efficient column handling and temperature control – the 1260 Infinity II Multicolumn Thermostat holds up to four columns with direct access to each column through a Quick-Change switching valve, delivering flexibility and eliminating the need to disconnect and reconnect columns.
  • Fast and easy connections – with InfinityLab Quick-Connect fittings to save time and trouble.
  • Higher quality data – the 1260 Infinity II Diode Array Detector HS delivers lower detection limits and higher data quality for more confidence. 
  • Efficient control, acquisition and reporting – Agilent’s Instrument Control Framework (ICF) enables smooth control of Agilent LC instrumentation through third-party chromatography data systems.

Routine analytical LC at lowest cost of ownership

The 1220 Infinity II LC is an integrated system for routine HPLC and UHPLC analysis in analytical and QA/QC labs. Based on the proven technology of the InfinityLab LC Series, the system's high quality and high performance help you to achieve maximum return on investment and lowest cost of ownership from day one. You can choose from four affordable, "all-in-one" configurations while upgrade paths allow you to increase system capability as your needs change. The walk-up upgrade and software convert the 1220 Infinity II LC into the perfect LC or LC/MS workhorse for a multi-user environment. Almost any InfinityLab LC Series module can be connected to give you maximum flexibility. 

Key features

  • Optimized for everyday productivity - exceptional accuracy and superior precision for all routine applications.
  • Fully compliant with all requirements for regulatory LC applications.
  • Industry leading quality and long-life - a member of the reliable and trusted InfinityLab LC Series.
  • Fast, trouble-free startup - every system is tested in its final configuration.
  • Flexibility - hardware choices and all-in-one configurations include an isocratic or gradient pump, manual injector or vial autosampler, column oven and variable wavelength detector.
  • Future proof - upgrade your system with additional hardware modules such as an InfinityLab LC Series refractive index, fluorescence or evaporative light scattering detector, or a 6000 Series single quadrupole MS.
  • Walk-up Solution - external walk-up tray and dedicated walk-up software make this the perfect LC system for a multi-user environment.
  • Mobile Lab - unique mobile upgrade allows installation of the 1220 Infinity II LC in a mobile lab.
  • Higher resolution and faster run times - our optimized pump delivers up to 600 bar so you can use smaller particle size columns.
  • Lower detection limits using a variable wavelength detector up to 80 Hz.
  • Maintain stable temperatures with the optional column oven.
  • High performance software - chose either OpenLAB CDS EZChrom Edition or the fully flexible, multi-purpose OpenLAB CDS ChemStation Edition.
1260 Infinity II Prime LC System

The Agilent 1290 Infinity II LC System embodies the next generation of UHPLC—with the exceptional reliability and robustness you expect from Agilent, plus breakthrough technologies to maximize the efficiency of your business. The 1290 Infinity II LC delivers unmatched separation and detection performance for ultimate confidence in your results. Highest sample capacity and fastest injection cycles help you to achieve highest throughput for any application. Seamless integration into your current laboratory infrastructure and smooth method transfer from legacy equipment facilitates nondisruptive transition to highest productivity and lowest total cost of ownership (TCO).

Key features

  • More chromatographic resolution – specially designed components in the sample flow path achieve lowest system dispersion.
  • Higher peak capacity for challenging separations – switch easily between single dimension UHPLC and the ultimate chromatographic power of 2D-LC.
  • Lower carryover for uncompromised data quality – multiwash capabilities of the 1290 Infinity II Multisampler reduce carryover to less than 10 ppm even for challenging compounds such as chlorohexidine.
  • Unique detection capabilities – combine lowest detection limits with an ultrawide dynamic range by using the new 1290 Infinity II HDR-DAD or 1290 Infinity II ELSD.
  • Faster injection cycles with dual-needle injection – for higher sample throughput.
  • Higher sample capacity per bench space – up to 6144 samples within the footprint of a standard Agilent stack.
  • Significantly better usability – dead-volume-free UHPLC fluidic connections can be easily achieved by the revolutionary InfinityLab Quick Connect fittings.
  • Flexibility for all applications – through wide power, temperature, and automatically scalable injection range, and gradient options.
  • Seamless transfer of methods between LCs, regardless of the brand – facilitated by Intelligent System Emulation Technology (ISET) delivering unchanged retention time and peak resolution.
  • Seamless integration in your chromatography data system – Agilent InfinityLab LC instrumentation runs smoother when controlled through third-party chromatography data systems such as Waters Empower or Thermo Scientific’s Chromeleon using the Agilent Instrument Control Framework (ICF)
  • Lower total cost of ownership – select from a variety of tools to achieve lowest cost-per-sample.
Agilent TechnologiesAgilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent’s expertise and trusted collaboration give them the highest confidence in our solutions.
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