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Extensive portfolio of LC/MS instruments

Agilent’s portfolio of LC/MS instruments takes the versatility of HPLC separation to another level with the sensitivity and specificity of mass spectrometry. 

Add easy-to-use mass selective detection to your HPLC analyses with single quadrupole (SQ) LC/MSD. Achieve quantitative precision with triple quadrupole (TQ) systems that break sensitivity and size barriers. Go untargeted and see more while identifying unknowns using time-of-flight (TOF/Q-TOF) technology that delivers simultaneous accuracy, speed, and isotopic fidelity. The reliable family of Agilent LC/MS instruments provides a range of capability and performance to solve any LC/MS analysis challenge.

Available models

The Agilent 6545 LC/Q-TOF raises the standard for mid-range high resolution accurate mass performance. Designed for untargeted analysis, it enables broad screening, comprehensive profiling, and identification of unknowns. 

Agilent’s 6545 LC/Q-TOF MS delivers sensitivity, resolution, mass accuracy, wide in-spectrum dynamic range, isotopic fidelity, and speed in one measurement. SWARM autotune enables optimal performance for everyone, specific to their application. The system couples excellent sensitivity with precise quantitative accuracy, reducing the number of replicates needed or the size of a study.

Key features

  • SWARM autotune improves sensitivity up to 5x for small molecule applications, and preserves labile compounds for improved detection
  • Get stable mass accuracy day after day with improvements delivered by Agilent time of flight electronics design
  • Stable sensitivity, driven by orthogonal Agilent Jet Stream ionization and optics shared with LC/TQ
  • Enhanced gain shifted detector increases life time up to 3X

The Agilent 6545XT AdvanceBio LC/Q-TOF system is designed to handle multiple workflows in biopharmaceutical characterization. When you need to access the most information at the intact protein level, automatically confirm a sequence through peptide mapping, and confidently understand PTMs, Agilent provides a UHPLC Q-TOF that delivers.

Accurately profile major and minor proteoforms with time-of-flight technology offering new levels of sensitivity and clarity to intact protein mass spectrometry. Easily dig deeper into peptide digests with the Iterative MS/MS mode of operation. The 6545XT AdvanceBio Q-TOF is the analytical cornerstone in a comprehensive set of tools designed for biopharma.

Key features

  • Get up and running fast with quick-start methods that include Agilent AdvanceBio LC columns for intact protein  and peptide workflows.
  • Characterize both major and minor intact protein variations with an automated data workflow featuring MassHunter BioConfirm software.
  • Adapt your instrument to your needs with SWARM autotune to ensure optimum performance with no manual adjustment. New large molecule setting provides sub-nanogram detection levels for intact glycosylated monoclonal antibodies.
  • Be sure of your results with mass accuracies within 10 ppm for glycosylated intact proteins.
  • Dig deeper into your digested samples with the powerful new iterative MS/MS feature.
  • Maximize your uptime with a system tested to perform through thousands of protein injections without degradation of performance.
  • Minimize maintenance delays with vent-free cleaning of entrance optics.

The Agilent 6560 Ion Mobility Q-TOF LC/MS system delivers unrivaled separation and selectivity by combining chromatography, ion mobility, and mass spectrometry. The 6560 Q-TOF mass spectrometer can even uncover structural information that cannot be seen with traditional high-resolution LC/MS systems. 

The system features innovative electrodynamic ion funnel technology to dramatically improve sensitivity while maintaining an attractive low field drift tube design. This allows you to directly calculate collision cross sections (CCS) and preserve labile targets. Whether you are looking to create a more comprehensive profile of metabolomics samples, characterize complex polymeric mixtures, or understand structural changes in biomolecules, ion mobility provides access to new information.

Key features

  • The gold standard in direct collision cross section measurement and accuracy
  • Achieve the utmost in separation capacity by combining UHPLC, ion mobility, and high resolution mass spectrometry
  • Better separation of complex isobaric classes such as lipids and glycans 
  • In-depth characterization of structural conformations and isomeric compounds
  • Low energy drift tube design to conserve structural fidelity of molecules in the gas phase

Whether you need to identify, screen, profile, or perform quantitation on complex samples, Agilent Q-TOF is ready. When simultaneous speed, sensitivity, accuracy, and dynamic range come together, you get the most information from your samples. The immense detail revealed is harnessed by MassHunter software to provide answers you can trust. Find out how an Agilent Q-TOF can help solve metabolomics, pharmaceutical research, discovery proteomics, food safety, forensic toxicology, and environmental screening challenges.

Key features

  • 6530 Q-TOF LC/MS - Get the full power of high resolution accurate mass MS/MS detail in an instrument ready for research or routine applications.
  • 6545 Q-TOF LC/MS - Expert level performance in an instrument designed for intensive daily use.
  • 6545XT AdvanceBio LC/Q-TOF - Designed to be the cornerstone of multiple biopharma workflows, with exceptional intact protein performance.
  • 6550 iFunnel Q-TOF LC/MS – Achieve femtogram-level sensitivity–  iFunnel increases ion transfer to achieve the lowest detection levels of any high resolution LC/MS instrument.
  • 6560 Ion Mobility Q-TOF LC/MS – Reveal greater detail with unmatched ion mobility performance for an added dimension of separation.
  • Increase dynamic range – In-spectrum dynamic range of up to 5 orders of magnitude to accurately profile and screen complex samples with trace-level targets in the presence of more abundant components.
  • Speeds of up to 50 spectra/second to take full advantage of the latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces.
  • Improve sensitivity for high-throughput applications – Agilent Jet Stream technology combined with improved ion optics provide 5x greater on-column sensitivity and increase up time to maintain the highest sensitivity for high throughput applications.
  • Powerful MassHunter Suite Software takes advantage of accurate mass MS and MS/MS and high definition isotopic data to facilitate profiling, characterization, identification and quantification of compounds in complex mixtures.
  • New All Ions MS/MS Technique for Targeted and Untargeted Screening on TOF and Q-TOF LC/MS

Raise your analysis to a new level with the Agilent 6530 Quadrupole Time-of-Flight LC/MS system. The 6530 delivers the power of high-resolution, accurate-mass MS/MS, so you can be fully confident of your data.

Key features

  • Mass accuracy within 2 ppm gives you complete confidence in your analysis.
  • Powerful Agilent Jet Stream source enables you to uncover low level components.
  • Wide in-spectrum dynamic range facilitates simultaneous measurement of minor components in the presence of intense background interferences. 
  • The latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces give you blazing fast acquisition speed.
  • Powerful MassHunter software provides the latest software capabilities for profiling, characterizing, identifying, and quantifying compounds in complex mixtures via high-definition MS and MS/MS.
  • Check out the latest developments in untargeted screening and quantitation using Agilent’s All Ions MS/MS technique.

When you need maximum sensitivity and mass accuracy, the 6550 iFunnel Q-TOF LC/MS system offers unprecedented detection levels in a high-resolution instrument.

Key features

  • Achieve femtogram-level sensitivity with Agilent iFunnel technology, which increases ion transfer for the lowest detection levels of any high-resolution LC/MS instrument.
  • Avoid interferences and make high-resolution quantitation a reality with the combination of accuracy and sensitivity.
  • Gain confidence in your analysis with sub-ppm mass accuracy and resolution of 45k.
  • See everything when screening or profiling with a wide in-spectrum dynamic range, complementing the system’s excellent detection limits and superb reproducibility. 
  • Take full advantage of blazing fast acquisition speeds with the latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces.
  • Use powerful MassHunter software for profiling, characterizing, identifying, and quantifying compounds in complex mixtures via high-definition MS and MS/MS.
  • Check out the latest developments in untargeted screening and quantitation using Agilent’s All Ions MS/MS technique.
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Agilent TechnologiesAgilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent’s expertise and trusted collaboration give them the highest confidence in our solutions.