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Extensive portfolio of LC/MS instruments

Agilent’s portfolio of LC/MS instruments takes the versatility of HPLC separation to another level with the sensitivity and specificity of mass spectrometry. 

Add easy-to-use mass selective detection to your HPLC analyses with single quadrupole (SQ) LC/MSD. Achieve quantitative precision with triple quadrupole (TQ) systems that break sensitivity and size barriers. Go untargeted and see more while identifying unknowns using time-of-flight (TOF/Q-TOF) technology that delivers simultaneous accuracy, speed, and isotopic fidelity. The reliable family of Agilent LC/MS instruments provides a range of capability and performance to solve any LC/MS analysis challenge.

Available models

Technical specifications
MRM sensitivity IDL; ESI positive
IDL < 10.0 fg
  • Measured using 20 fg reserpine on-column
  • Quantifying on the MRM transition of  m/z 609 to m/z 195
  • Tested during manufacturing and confirmed on-site during installation

Ultivo is a stackable Liquid Chromatography Triple Quadrupole (LC/TQ) mass spectrometer that eliminates the MS footprint by incorporating the MS into the LC stack, and represents a transformative approach to LC/TQ. Ultivo triple quadrupole LC/MS provides the performance found in larger comparable systems, but at a fraction of their size. 

Innovations such as the Vortex Collision Cell, Cyclone Ion Guide, and VacShield provide users the sensitivity, robustness, reliability, and performance required for the day-in, day-out challenges of high-throughput sample analysis. Now with the addition of an ESI-only model, and features geared to assist you with 21 CFR Part 11 compliance, the Ultivo LC/TQ continues to reshape expectations, reinvent capabilities, and redefine what’s possible when small meets powerful.

Key features

  • Smallest footprint of any LC/TQ on the market, delivering a price-performance per square foot ratio that leads to reduced costs and the fastest path to achieving ROI.
  • Greater signal and reduced noise – Agilent Jet Stream Technology uses super-heated nitrogen to improve ion generation and desolvation
  • Instrument innovations for enhanced results:
    • VacShield – eliminates the need to vent the system while performing ion injector maintenance so instrument maintenance downtime is minimized and laboratory efficiency is increased.
    • Cyclone Ion Guide – compresses the ion beam without loss of signal, resulting in higher ion transmission efficiencies and enhanced data quality.
    • Vortex Collision Cell – provides efficient dissociation of ions in the cell, improved focusing and transmission of ions, rapid clearance of the cell between mass transitions, thereby allowing for more MRMs/sec, zero crosstalk and greater confidence in results by removing noisy background.
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantification with the generation of a product ion spectrum for compound screening and confirmation.
  • The intuitive operational design of the “Quant-My-Way” software feature and the MassHunter Productivity App provide boosts in productivity by up to 40%: require less need for operator training, reduce time reviewing data and simplify report generation.
  • Enhanced Maintenance Feedback (EMF) features centered on smart, self-aware diagnostics ensure optimum uptime and help to drive down maintenance costs
  • Combine with MassHunter software, OpenLab ECM 3 series (3.5 and above software ) and IQ/OQ services provide data integrity tools to assist you in achieving compliance readiness.
  • Optimized for unparalleled performance and advanced efficiency when paired with Agilent’s market leading portfolio of analytical LC systems and associated consumables.
  • Put CrossLab services to work for you; consultative support for workflow enablement, lab analytics, compliance, inventory management, asset management and relocation services

With its dual ion-funnel design, the Agilent 6495B triple quadrupole LC/MS system is ideally suited for peptide quantitation, food safety, environmental testing, forensics, clinical research, and other demanding applications. The Agilent Jet Stream ion source, hexabore capillary, and curved geometry collision cell combine to deliver the utmost in sensitivity among commercially available TQ LC/MS. The enhanced performance of this tandem quadrupole mass spectrometer makes it a perfect option for applications where you need extended mass range as well as consistent day-in, day-out operation. 

The Agilent 6495B triple quadrupole LC/MS system is at the forefront of robustness. It even includes a gate-valve assembly for quick and efficient maintenance of the hexabore capillary. Make this sensitive yet rugged instrument the cornerstone to your workflow.

Key features

  • Agilent's most sensitive LC/TQ –  up to attomole-zeptomole levels using iFunnel Technology
  • Enhanced assay performance using efficient ion sampling and transmission
  • Reliable and robust performance from enhanced ion optic lenses
  • Efficient ion detection and quantification using high-energy conversion dynode and low-noise characteristics
  • Gate Valve Technology – perform ion source maintenance without having to vent the instrument 
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantification with the generation of a product ion spectrum for library searching and compound screening and confirmation

The Agilent 6470A triple quadrupole LC/MS system delivers robust performance for commercial, regulatory, life sciences, and research applications. The 6470A UHPLC MS/MS system employs two technological advantages: Agilent Jet Stream ion source and curved geometry collision cell. These innovations enable you to reliably detect target compounds at low levels in diverse matrices, while achieving wide linear dynamic range. 

The 6470A LC/MS/MS triple quadrupole provides best-in-class sensitivity, precision, and scan speed, so you can dilute or use less sample and still have complete confidence in the accuracy of your results. The system’s proven robustness and reliability mean less maintenance and more uninterrupted laboratory productivity.

Key features

  • Enhanced sensitivity - detection limits up to sub-femtogram level 
  • Greater signal and reduced noise - Agilent Jet Stream technology uses super-heated nitrogen to improve ion generation and desolvation.
  • Compact design – reduced benchtop footprint
  • Secure investment with the flexibility to upgrade to Agilent iFunnel Technology
  • Efficient collection and transmission of product ions from innovative curved and tapered hexapole assembly
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation

The Agilent 6420A Triple Quadrupole LC/MS System is equipped with performance specifications in Signal-to-Noise ratio (S/N) and Instrument Detection Limit (IDL) for routine analysis.

Key features

  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation.
  • Efficient analysis – fast MRM speeds allow for analysis of over 100 overlapping compounds in a given retention time window
  • Fast polarity switching for analysis of both positive and negative ions
  • Secure investment – upgradable to the Agilent 6460C with Agilent Jet Stream technology for greater signal and reduced noise

The Agilent 6460C Triple Quadrupole LC/MS System is equipped with Agilent Jet Stream Technology to enable enhanced sensitivity. The 6460 provides a fast and robust solution to simultaneously quantify, screen, and confirm analytes in the laboratory.

Key features

  • Greater signal and reduced noise - Agilent Jet Stream technology uses super-heated nitrogen to improve ion generation and desolvation
  • Efficient analysis – fast MRM speeds allow for analysis of over 100 overlapping compounds in a given retention time window
  • Screen, confirm and quantify – Triggered MRM (tMRM) combines fast and sensitive MRM quantitation with the generation of a product ion spectrum for library searching and compound screening and confirmation
  • Fast polarity switching for analysis of both positive and negative ions

The Agilent 6545 LC/Q-TOF raises the standard for mid-range high resolution accurate mass performance. Designed for untargeted analysis, it enables broad screening, comprehensive profiling, and identification of unknowns. 

Agilent’s 6545 LC/Q-TOF MS delivers sensitivity, resolution, mass accuracy, wide in-spectrum dynamic range, isotopic fidelity, and speed in one measurement. SWARM autotune enables optimal performance for everyone, specific to their application. The system couples excellent sensitivity with precise quantitative accuracy, reducing the number of replicates needed or the size of a study.

Key features

  • SWARM autotune improves sensitivity up to 5x for small molecule applications, and preserves labile compounds for improved detection
  • Get stable mass accuracy day after day with improvements delivered by Agilent time of flight electronics design
  • Stable sensitivity, driven by orthogonal Agilent Jet Stream ionization and optics shared with LC/TQ
  • Enhanced gain shifted detector increases life time up to 3X

The Agilent 6545XT AdvanceBio LC/Q-TOF system is designed to handle multiple workflows in biopharmaceutical characterization. When you need to access the most information at the intact protein level, automatically confirm a sequence through peptide mapping, and confidently understand PTMs, Agilent provides a UHPLC Q-TOF that delivers.

Accurately profile major and minor proteoforms with time-of-flight technology offering new levels of sensitivity and clarity to intact protein mass spectrometry. Easily dig deeper into peptide digests with the Iterative MS/MS mode of operation. The 6545XT AdvanceBio Q-TOF is the analytical cornerstone in a comprehensive set of tools designed for biopharma.

Key features

  • Get up and running fast with quick-start methods that include Agilent AdvanceBio LC columns for intact protein  and peptide workflows.
  • Characterize both major and minor intact protein variations with an automated data workflow featuring MassHunter BioConfirm software.
  • Adapt your instrument to your needs with SWARM autotune to ensure optimum performance with no manual adjustment. New large molecule setting provides sub-nanogram detection levels for intact glycosylated monoclonal antibodies.
  • Be sure of your results with mass accuracies within 10 ppm for glycosylated intact proteins.
  • Dig deeper into your digested samples with the powerful new iterative MS/MS feature.
  • Maximize your uptime with a system tested to perform through thousands of protein injections without degradation of performance.
  • Minimize maintenance delays with vent-free cleaning of entrance optics.

The Agilent 6560 Ion Mobility Q-TOF LC/MS system delivers unrivaled separation and selectivity by combining chromatography, ion mobility, and mass spectrometry. The 6560 Q-TOF mass spectrometer can even uncover structural information that cannot be seen with traditional high-resolution LC/MS systems. 

The system features innovative electrodynamic ion funnel technology to dramatically improve sensitivity while maintaining an attractive low field drift tube design. This allows you to directly calculate collision cross sections (CCS) and preserve labile targets. Whether you are looking to create a more comprehensive profile of metabolomics samples, characterize complex polymeric mixtures, or understand structural changes in biomolecules, ion mobility provides access to new information.

Key features

  • The gold standard in direct collision cross section measurement and accuracy
  • Achieve the utmost in separation capacity by combining UHPLC, ion mobility, and high resolution mass spectrometry
  • Better separation of complex isobaric classes such as lipids and glycans 
  • In-depth characterization of structural conformations and isomeric compounds
  • Low energy drift tube design to conserve structural fidelity of molecules in the gas phase

Whether you need to identify, screen, profile, or perform quantitation on complex samples, Agilent Q-TOF is ready. When simultaneous speed, sensitivity, accuracy, and dynamic range come together, you get the most information from your samples. The immense detail revealed is harnessed by MassHunter software to provide answers you can trust. Find out how an Agilent Q-TOF can help solve metabolomics, pharmaceutical research, discovery proteomics, food safety, forensic toxicology, and environmental screening challenges.

Key features

  • 6530 Q-TOF LC/MS - Get the full power of high resolution accurate mass MS/MS detail in an instrument ready for research or routine applications.
  • 6545 Q-TOF LC/MS - Expert level performance in an instrument designed for intensive daily use.
  • 6545XT AdvanceBio LC/Q-TOF - Designed to be the cornerstone of multiple biopharma workflows, with exceptional intact protein performance.
  • 6550 iFunnel Q-TOF LC/MS – Achieve femtogram-level sensitivity–  iFunnel increases ion transfer to achieve the lowest detection levels of any high resolution LC/MS instrument.
  • 6560 Ion Mobility Q-TOF LC/MS – Reveal greater detail with unmatched ion mobility performance for an added dimension of separation.
  • Increase dynamic range – In-spectrum dynamic range of up to 5 orders of magnitude to accurately profile and screen complex samples with trace-level targets in the presence of more abundant components.
  • Speeds of up to 50 spectra/second to take full advantage of the latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces.
  • Improve sensitivity for high-throughput applications – Agilent Jet Stream technology combined with improved ion optics provide 5x greater on-column sensitivity and increase up time to maintain the highest sensitivity for high throughput applications.
  • Powerful MassHunter Suite Software takes advantage of accurate mass MS and MS/MS and high definition isotopic data to facilitate profiling, characterization, identification and quantification of compounds in complex mixtures.
  • New All Ions MS/MS Technique for Targeted and Untargeted Screening on TOF and Q-TOF LC/MS

Raise your analysis to a new level with the Agilent 6530 Quadrupole Time-of-Flight LC/MS system. The 6530 delivers the power of high-resolution, accurate-mass MS/MS, so you can be fully confident of your data.

Key features

  • Mass accuracy within 2 ppm gives you complete confidence in your analysis.
  • Powerful Agilent Jet Stream source enables you to uncover low level components.
  • Wide in-spectrum dynamic range facilitates simultaneous measurement of minor components in the presence of intense background interferences. 
  • The latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces give you blazing fast acquisition speed.
  • Powerful MassHunter software provides the latest software capabilities for profiling, characterizing, identifying, and quantifying compounds in complex mixtures via high-definition MS and MS/MS.
  • Check out the latest developments in untargeted screening and quantitation using Agilent’s All Ions MS/MS technique.

When you need maximum sensitivity and mass accuracy, the 6550 iFunnel Q-TOF LC/MS system offers unprecedented detection levels in a high-resolution instrument.

Key features

  • Achieve femtogram-level sensitivity with Agilent iFunnel technology, which increases ion transfer for the lowest detection levels of any high-resolution LC/MS instrument.
  • Avoid interferences and make high-resolution quantitation a reality with the combination of accuracy and sensitivity.
  • Gain confidence in your analysis with sub-ppm mass accuracy and resolution of 45k.
  • See everything when screening or profiling with a wide in-spectrum dynamic range, complementing the system’s excellent detection limits and superb reproducibility. 
  • Take full advantage of blazing fast acquisition speeds with the latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces.
  • Use powerful MassHunter software for profiling, characterizing, identifying, and quantifying compounds in complex mixtures via high-definition MS and MS/MS.
  • Check out the latest developments in untargeted screening and quantitation using Agilent’s All Ions MS/MS technique.
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Agilent TechnologiesAgilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent’s expertise and trusted collaboration give them the highest confidence in our solutions.
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