Waters mass spectrometers provide you with the tools to confidently identify and quantify unknown compounds in complex samples, and confirm trace components at the lowest possible levels. Instrumentation that allows you to comprehensively catalog complex samples in a single analysis is now available. With technologies like QuanTof (for a new dimension in high-resolution exact mass MS), StepWave (for confirmation of trace components), Triwave (for characterization of complex mixtures), and MSE (for exact-mass ion spectra from your samples), your possibilities are endless.
Single quad technology is a well respected, robust and reliable mass detection technique for many different functional areas of LC-MS across many different industries. Designed for compatibility with UPLC, UPSFC, HPLC, and AutoPurification, and with a wide range of ionization options, single quadrupole mass detection is an easy way to generate an extra dimension of information from your separation.
The Power of Knowing Now
Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times; integrating direct MS analysis can drive multiple system-wide efficiencies helping to achieve your operational goals. Combining flexibility, ease of operation and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.
Press On to Bring the Power of Mass Detection to Your Lab
With great detection power comes great possibility – Minimize the risk of unexpected coelutions or components and confirm trace components with the analytical confidence of mass detection. Enhance the analytical value and productivity of each analysis.
Designed for the routine, prepared for the unexpected
Compatible with the broadest range of chromatography platforms and ionization sources, the SQ Detector 2 is the ultimate single quadrupole mass detector for chromatography.
Waters innovative tandem quadrupole MS technology is designed for quantitative UPLC®-MS/MS. Our philosophy centers on making high performance accessible, robust, reliable.
One system. Every analyte. All the time.
Demands on analytical laboratories are changing and every laboratory needs to ensure it can keep pace with these changes. The Xevo® TQ-XS offers:
A step change in sensitivity with the Xevo TQ-S
Designed for the most demanding quantitative UPLC-MS/MS applications. The ultimate in tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness, available to everyone due to the accessibility of the Xevo platform.
High Performance from a Compact Design with Rapid, Reliable and Reproducible Quantitative Data
Revolutionary design has produced a tandem quadrupole instrument with a small footprint that delivers consistent low levels of quantitation with a wide dynamic range.
Transform your quantitative capabilities. Accessible reliable performance.
High performance quantitation, accessible to all. Routine testing doesn’t have to be limited – maximize your performance by expanding your analytes per injection and extending your validated concentration range, without increasing your lab footprint. Delivering purpose driven performance, so you can:
The rugged, robust and reliable Xevo TQD
The single vendor solution for routine quantitative UPLC-MS/MS applications, providing maximum accessibility to the sensitivity, selectivity and robustness needed to ensure maximum productivity with minimum effort.
The perfect addition to your laboratory
A robust EI and CI GC-MS/MS platform engineered to maximize uptime with:
Waters Time-of-flight MS systems, featuring QuanTof and MSE technologies, provide the highest UPLC-MS performance to meet the needs of challenging qualitative and quantitative applications.
BioAccord LC-MS System with ACQUITY Premier
The BioAccord LC-MS System with ACQUITY Premier is designed specifically for routine monitoring in biopharmaceutical process and product development.
Delivering SmartMS to the Masses
Increase productivity, improve data confidence and simplify routine accurate mass workflows with the new ACQUITY RDa Detector.
Compact, compliance-ready and easy-to-use, this LC-MS system ensures your entire laboratory can easily access high resolution mass measurements to instantly start working smarter, not harder.
Performance, robustness, and flexibility made accessible to everyone
For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.
The First Smart MS-Enabled Biopharma Solution
Engineered Simplicity
The BioAccord LC-MS System is the first SmartMS-enabled biopharmaceutical solution. This compact, self-optimizing system has a built-in health check that ensures the system is always generating data of the required quality.
The simplicity provided by SmartMS means that the BioAccord generates the same high-quality results whether you are an LC-MS expert or a new user.
Waters Quadrupole Time-of-flight MS systems, featuring ion mobility, QuanTof, Fast DDA and MSE technologies, provide the highest UPLC-MS/MS performance to meet the needs of challenging qualitative and quantitative applications.
Without discovery, decisions are made in the dark
In the arena of scientific discovery, the slow pace of advancement and escalating costs of research can prove to be a challenge. The SYNAPT XS mass spectrometer shatters these barriers by providing ultimate flexibility and greater freedom of analytical choice to support scientific creativity and technical success for any application.
Ultimate power, ultimate performance. Redefine the boundaries of science.
Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.
eXtreme Sensitivity, eXtraordinary Selectivity, eXceptional Solutions
For the scientist who needs to identify, quantify and confirm the broadest range of compounds in the most complex and challenging samples.
Beyond Resolution
Do you have the vision to see what others don’t see? The risk of not seeing everything in your sample – or not seeing everything clearly - can be high, especially if this results in incorrect identifications or time-consuming additional confirmatory experiments. Vion IMS QTof dramatically reduces this risk as it has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling you to:
Yield comprehensive results with combined imaging techniques
Unique to the SYNAPT XS and SELECT SERIES MRT, Full Spectrum Molecular Imaging (FSMI) represents a combination of advanced Mass Spectrometry (MS) imaging technologies, integrating DESI, MALDI, and ion mobility mass spectrometry through a dedicated imaging informatics solution. Waters’ FSMI system provides detailed molecular information that exceeds any single MS imaging technique currently available, delivering high quality, comprehensive, spatially resolved molecular information across a variety of application areas, and with the minimum of time and effort.
From research to routine - use ion mobility to enhance your analyses
Our range of IMS instruments will instill greater confidence in all your findings and with three to choose from, we have an instrument that will be just right for you. The SELECT SERIES Cyclic IMS, Waters SYNAPT XS and Vion IMS systems all combine ion mobility separations with high resolution MS, significantly enhancing the information available to you compared to MS alone, and enabling you to access information that would otherwise not be possible.
Ultimate power, ultimate performance. Redefine the boundaries of science.
Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.
Without discovery, decisions are made in the dark
In the arena of scientific discovery, the slow pace of advancement and escalating costs of research can prove to be a challenge. The SYNAPT XS mass spectrometer shatters these barriers by providing ultimate flexibility and greater freedom of analytical choice to support scientific creativity and technical success for any application.
Redefining Resolution - Resolution in 3 Dimensions
Information. Informatics. Impact. SYNAPT provides the most complete characterization of complex mixtures and molecules with unique levels of MS performance, industry leading informatics and unparalleled platform versatility.
Redefining Resolution - Resolution in 3 Dimensions
MALDI SYNAPT G2-Si is a uniquely powerful and versatile MS platform. It's the only way to combine multiple dimensions of separation for analysis of complex samples, from imaging to biological research to chemical materials characterization.
Beyond Resolution
Do you have the vision to see what others don’t see? The risk of not seeing everything in your sample – or not seeing everything clearly - can be high, especially if this results in incorrect identifications or time-consuming additional confirmatory experiments. Vion IMS QTof dramatically reduces this risk as it has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling you to:
When you need to extract the maximum amount of information from a diverse range of compounds, you require the ultimate in ionization flexibility and performance. Providing the highest performance, without compromise, the ionization source options are quick and easy to interchange enabling the widest range of ionization techniques to be utilized universally across a single analytical platform.
A novel ion source for ionization of a broader range of compounds
The UniSpray™ ion source allows you to see more of your sample within a single analysis when compared to ESI, APCI or APPI. This enables UniSpray to offer:
Enhanced MS with the Turn of a Key
The ionKey/MS System redefines ultimate performance by integrating microflow UPLC directly into the source of the mass spectrometer. This provides an increased level of sensitivity, chromatographic performance, and ease-of-use that cannot be achieved any other way.
APGC – No Compromise GC-MS
Waters Atmospheric Pressure Gas Chromatography (APGC) adds GC capability to today’s advanced MS technologies. This provides GC users with:
Make Exact Mass Measurements Easy
The LockSpray dual electrospray ion source optimizes the co-introduction of analyte and lock mass compound directly into the ion source, providing authenticated exact mass measurement in MS and MS/MS modes to within 5 ppm RMS mass accuracy (3 ppm for Xevo QTof MS and 1 ppm for Xevo G2 Tof series, Xevo G2 QTof series and SYNAPT G2 series).
The increased specificity associated with exact mass measurement provides you with improved efficacy in compound or fragment identification in metabolite profiling and proteomics applications.
Traditionally, to obtain valid exact mass measurement, an internal reference or “lock mass” was used to correct for changes in environment or experimental conditions over the course of the analysis. This was achieved by “teeing in” a suitable reference compound to the main analyte flow. However, this approach often suffered from ionization suppression, potential mass interferences and solvent gradient effects.
Exact Mass Measurement in Both NanoFlow LC-MS and LC-MS/MS Modes
The NanoLockSpray dual electrospray ion source provides authenticated exact mass measurement in both NanoFlow LC-MS and LC-MS/MS modes of operation. It features the optimized co-introduction of analyte and lock mass compounds directly into the ion source offering a superior alternative for the acquisition of exact mass data.
The increased specificity associated with exact mass measurement improves efficacy in compound or fragment identification with metabolite profiling and proteomics applications.
Atmospheric Pressure Chemical Ionization (APCI) is an effective method for analyzing lower-polarity compounds. The high-efficiency IonSABRE™APCI probe offers significant improvements in sensitivity compared with earlier versions of probe, particularly at higher liquid flow rates.
Ionization Process
With APCI, the sample stream is nebulised and analytes are desolvated using a combination of gas flow and high temperatures. The desolvated compounds are ionized by charge transfer as they pass through a plasma created by a corona discharge. Flow rates up to 2 ml/min are acceptable.
The IonSABRE APCI probe with thermally enhanced heater design provides improved heat distribution and sample vaporization. The support gas flow also maximizes transmission of sample droplets into the ion source. Together, these features provide optimum APCI performance leading to superior limits of quantitation in compound quantification and identification studies.
Rapid Direct Analysis of Volatile and Semi-Volatile, Solid and Liquid Samples
The Atmospheric Solids Analysis Probe* (ASAP) (introduced by McEwan et al) is a useful tool for the rapid direct analysis of volatile and semi-volatile, solid and liquid samples using atmospheric pressure ionization.
The ASAP technique utilizes the heated nitrogen desolvation gas to vaporize the sample and a corona discharge for sample ionization. This allows low polarity compounds not amenable to ESI, APcI and APPI to be ionized with a high degree of sensitivity. Furthermore complex mixtures can be analyzed without the need for any sample preparation.
Imaging mass spectrometry is a technique that allows chemical information to be obtained directly or via the use of matrices from a wide range of surfaces. MS Imaging provides information on the spatial distribution of molecules at or near the surface. Imaging provides beautiful and information-rich images that allow scientists to answer the fundamental question: “Where is this component in my sample?”
All the benefits of time-of-flight technology. Redefined performance.
Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology.