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Platelet Testing

Platelets are small, round blood cells that help with blood clotting. Also known as thrombocytes, platelets play an important role in healthy blood functions and platelet function tests are widely used to evaluate how well a person’s platelets work to stop bleeding within the body. A normal platelet count is from 150,000 to 450,000 per microliter of blood, and can be both too high or too low, known as thrombocytopenia. A normal platelet count can still be problematic if the cells are functioning poorly, known as platelet dysfunction.

Platelets are produced in the bone marrow and circulated within the bloodstream, where they will arrive to injury sites and start the clotting process. Platelets achieve clotting in three ways:

  • Adhere to the injury site by growing tentacles that attach to each other and the injured surface
  • Aggregate to form a plug on the injury site
  • Release compounds that stimulate further aggregation and guide immune cells to the injury site


Various platelet diagnostics methods are used clinically to evaluate a person’s natural ability to blood clot and heal wounds.

Many different substances can activate a platelet, and platelet abnormalities can be due to a combination of multiple pathways to failure. Platelet aggregometry consists of a suite of reagent substances known as agonists, that are added to the blood, followed by optical measurements of the aggregation over time. Although complicated to perform and interpret, the platelet aggregation method is considered the gold standard, and may be ordered by physicians when a more rapid method is inconclusive or unsuitable, or as a confirmatory test.

Lumiaggregometry uses ATP luminescence to measure the release of certain organic agents from platelet granules. This measurement is used to identify platelet dysfunctions that affect its ability to aggregate, such as grey platelet syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.

Related Products

Chrono-log Model 700
Lumi-Aggregation Performed in up to four (4) PRP or Whole Blood Samples

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