Due to the number of reagents and pipetting steps required in PCR and NGS workflows, liquid handling is integral to a host of genomics applications ranging from research to diagnostics. High throughput genomic labs can use liquid handling robots to automatically process their samples in a sample-to-result fashion, reducing turnaround time, hands-on time, and the number of touchpoints. In some cases, instruments come integrated with liquid handling or pre-optimized to fit into automation workflows.
Drug discovery has evolved to become a very high throughput field of work, often involving thousands to millions of samples tested in the span of weeks, with the goal of finding the best drug candidate to further characterize and develop. Liquid handling can be integrated to many drug discovery workflows in both small molecules and biologics. Examples include compound management, assay development, biochemical and cell-based screening, cell culturing, antibody/protein production and purification, ADME-Tox assays, and genomics workflows.
Target identification and validation
Cell lines and primary cells are widely used for the production of cell-derived biomolecules, as well as for cell-based assays. Liquid handling and automation can be applied to a host of solutions, including cell culturing, cloning, transfections, colony picking, assays, and cellular analysis. In the field of cell and gene therapy, complex and precious cells such as iPSCs can be handled in an automated way to ensure production and analysis quality.
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