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Pesticides are widely used in producing food to control pests such as insects, rodents, weeds, bacteria, mold and fungus. As they are intrinsically toxic and deliberately spread in the environment, the production, distribution, and use of pesticides require strict regulation and control. Regular monitoring of residues in food and the environment is also required.

Chromatography combined with mass spectrometry is the technique of choice for pesticide analysis. Combined LC/MS and GC/MS multi-residue methods often cover the majority of compounds of interest.